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Import Imports System.Text.RegularExpressions
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            'regularExpression_Match -> regular expression pattern to macth
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            Dim regularExpression_Match As New Regex("(.*)REGULAR EXPRESSION MATCH PATTERN(.*)")
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            'txtInput.txt -> Text to macth against regularExpression_Match pattern
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            Dim myMatch As Match = System.Text.RegularExpressions.Regex.Match(txtInput.Text, regularExpression_Match)
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            If myMatch.Success Then
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                'Do Something
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            End If

 vb.net | 
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If Regex.IsMatch( userInputString, "\d+(\.?\d+)" ) Then
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    ' perform some conversion and math operations here
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End If 

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                    Try
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                        'regularExpression_Replace -> regular expression pattern to replace
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                        Dim regularExpression_Replace As New Regex("(.*)REGULAR EXPRESSION REPLACE PATTERN(.*)")
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                        'txtInput.txt -> Text to macth and replace against 
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                        Dim txtReplacementPattern As String
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                        txtReplacementPattern = "THIS WILL BE MY REPLACED TEXT"
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                        'txtReplacementPattern = "$ "
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                        txtInput.Text = regularExpression_Replace.Replace(txtInput.Text, _
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                            txtReplacementPattern)
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                    Catch ex As Exception
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                        Mess